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Previously described cardiovascular effects of GLP-1 RAs are primarily indirect and include enhanced endothelial function and myocardial metabolism, natriuresis and anti-inflammatory and blood pressure-lowering effects

Wegovy is administered once weekly via subcutaneous injection, typically in the abdomen, thigh, or upper arm

Semaglutide commonly causes nausea, vomiting, and diarrhea

Safety and Side Effects All three peptides have favorable safety profiles

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At the same time, experts agree that long-term success is most likely when medication is paired with nutrition education, physical activity, and appropriate mental health support