First isolated from human plasma in 1973 by Loren Pickart, it was discovered as an activity in human albumin that caused old liver tissue to synthesize proteins like younger tissue
The discussion of human studies on oral supplementation was kept brief and largely summarized findings from previous reviews of the topic as the focus is on inhaled delivery
USA 95 , 1309113096 (1998)
Proposed mechanisms include upregulation of growth-hormone-receptor expression in injured tissue, VEGF-driven angiogenesis, modulation of the nitric-oxide pathway in vascular endothelium, and activation of FAK-paxillin signaling
The rapid induction of glutathione S-transferases AtGSTF2 and AtGSTF6 by avirulent Pseudomonas syringae is the result of combined salicylic acid and ethylene signaling
But it sounds like some of these reparative pathways either should be explored in the context of brain injury or, I'm guessing are being explored in the context of brain injury
