Written informed consent to participate in this study was provided by the participants' legal guardian/next of kin
CYP24A1 is a mitochondrial enzyme that catalyzes the degradation of 1,25(OH) 2 D 3 to its less active 25-D3 form and regulates the amount of active Vitamin D in tissues
However, CBD-containing products may have trace amounts of THC or contain other cannabinoids, and such presence carries a risk of adverse analytical findings for THC
Methylcobalamin degrades more rapidly
Phase 1 CLEAR (Active Acne Treatment) Targets breakouts at the source by reducing clogged pores, bacteria, and inflammation Topical isotretinoin normalizes skin cell turnover and prevents clogged pores Topical clindamycin reduces acne-causing bacteria and inflammation (patients will experience short-term exposure to reduce antibiotic resistance) Additional supporting ingredients may be included based on patient needs Phase 2 FADE (Post-Acne Repair) Focuses on improving discoloration and restoring even skin tone following breakouts Topical isotretinoin continues to support cell turnover Tranexamic acid helps reduce hyperpigmentation and dark spots Niacinamide (Vitamin B3) supports the skin barrier and reduces redness Phase 3 RENEW (Maintenance & Skin Quality) Supports long-term skin health, texture, and overall appearance Topical isotretinoin maintains clear pores and ongoing renewal Copper peptide (GHK-Cu) supports skin repair and improves texture and firmness Unlike oral isotretinoin, which requires enrollment in the iPLEDGE risk management program and ongoing laboratory monitoring, Isoclear is delivered topically, enabling a more flexible, dermatologist-guided treatment approach without the same administrative burden associated with oral therapies
Intern Emerg Med 19, 275293 (2024)
