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Triple agonists such as retatrutide target GLP-1, GIP, and glucagon receptors and are still investigational

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Abdominal fat loss, as well as sustained reductions of fasting insulin levels and markers of IR, have been also shown to individuals with overweight/obesity, prediabetes, PCOS and OSA during their administration [31, 38, 6770]

However, other studies have demonstrated important effects of l-carnitine on oxidative stress, as in patients with renal disease [59], phenylketonuria [60], and nonalcoholic steatohepatitis [61], as well as on several experimental models of oxidative stress [6264]

Friedrichsen M, Breitschaft A, Tadayon S, Wizert A, Skovgaard D