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10.1016/j.gendis.2023.101138 68 O'rourkeS

Supplemental cysteine is available as L-cysteine and N-acetylcysteine (NAC)

FIGURE 1 FIGURE 2 Glutathione is synthesized in the cytosol of all cells from their precursor amino acids: glutamic acid, cysteine and glycine by consecutive action of two enzymes: -glutamyl-cysteine (-GluCys) synthetase (also known as glutamate cysteine ligase, GCL) that in a first step uses glutamate and cysteine as a substrate to form the dipeptide -glutamyl-cysteine

fo r Combining creates synergy : Using NAD+ and glutathione together provides comprehensive cellular health benefits, with NAD+ supporting energy while glutathione neutralizes oxidative byproducts