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A GRAS determination reflects a safety conclusion for a described food-ingredient use

Common Adverse Effects The most frequently reported complications include: Abdominal pain and cramping: Often severe and requiring medical attention Rectal burning and irritation: The coffee solution can damage delicate rectal and colonic tissue Bloody stools: Indicating intestinal injury or inflammation Proctocolitis: Inflammation of the rectum and colon lining that can become chronic Electrolyte imbalances: Particularly dangerous depletion of sodium and potassium Dehydration: From excessive fluid loss and electrolyte disturbances Life-Threatening Complications Most alarming are the documented fatalities associated with coffee enemas

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Espasiano, A

Platten M, Nollen EAA, Rohrig UF, Fallarino F, Opitz CA

acidity regulator: citric acid