438 Functional MRI studies have reported augmented blood oxygen level-dependent (BOLD) responses in limbic and striatal structures in response to heat pain in PDPN patients
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While promising in various experimental contexts, much remains under investigation, and findings continue to evolve
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Most reports of nausea, vomiting, and diarrhea occur when doses are being increased at the start of treatment
A key driver of this process is insulin resistance, which affects both hepatic and peripheral tissues, creating a metabolic environment that simultaneously promotes hyperglycemia and hepatic steatosis through selective pathway activation