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Excess accumulation of vitamin A in the liver can lead to toxicity which manifests as bone pain, hepatosplenomegaly, nausea and diarrhea

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Cons: Vary in absorption and efficiency, potentially longer periods to observe health benefits, no skin-lightening effect, and requires consistent long-term use to maintain levels

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Finally, the strain MG12345 was constructed by deleting glgB (Table 1)