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(PubMed) Hiatt WR

Ferroptosis describes a form of regulated cell death that is driven by unrestricted lipid peroxidation, which does not require the activation of caspase and can be suppressed by iron chelators, lipophilic antioxidants, inhibitors of lipid peroxidation, and depletion of polyunsaturated fatty acids

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Therefore, investigating the relationships among PUFAs, ferroptosis, and PF is crucial for advancing our understanding of PF pathogenesis and identifying potential new therapeutic targets