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Comorbidities included hypertensive diseases (I10-I16), Type 2 diabetes mellitus (E11), chronic lower respiratory diseases (J40-J47), neoplasms (C00-D49), psychoactive substance use (F10-F19), ischemic heart diseases (I20-I25), chronic kidney disease (N18), and cerebrovascular diseases (I60-I69)

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Observational studies and clinical practice suggest that these patients would benefit more from an LSG or RYBG intervention than LAGB, although there are currently no published randomised clinical trials showing the superiority of one procedure in terms of long-term glycaemic control and remission of T2DM [10, 34]

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"Lilly's phase 2 retatrutide results published in The New England Journal of Medicine show the investigational molecule achieved up to 17.5% mean weight reduction at 24 weeks in adults with obesity and overweight"

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Aptamer-functionalized nanoparticles targeting FLSs deliver JAK inhibitors, alleviating synovial hyperplasia (43)

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Genetic differences in MC1R can influence how this receptor responds to melanocortin signals, which may affect pigmentation traits, while broader melanocortin signaling also links to energy balance and reproductive biology

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Bagger JI, Knop FK, Lund A, ve dierleri

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