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The evidence base for transdermal B12 absorption is weak, well-conducted oral and sublingual studies show dramatically better absorption, and the patches cost more per effective dose

A lack of B12 can lead to anemia (not having enough red blood cells), which causes you to feel tired and weak

The studys limitations include the cross-sectional nature, which precludes establishing causality, self-reporting of anthropometric and demographic data, which might lead to bias, and unidentified confounding

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