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Guidelines recommend aiming for at least a 4-cm reduction in waist circumference

Los mecanismos mediante los cuales la GLP-1 reduce el apetito incluyen: Accin central en el sistema nervioso: La GLP-1 atraviesa la barrera hematoenceflica en reas especficas o activa vas neurales aferentes que transmiten seales de saciedad al cerebro

Zhang Q, Li Q, Liu S, Zheng H, Ji L, Yi N et al (2022) Glucagon-like peptide-1 receptor agonist attenuates diabetic neuropathic pain via inhibition of NOD-like receptor protein 3 inflammasome in brain microglia

A large retrospective study of over 18,000 patients found that those taking tirzepatide lost approximately 15.3% of body weight in one year compared to 8.3% with semaglutide

Theory 24 , 530536 (1978)