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Stemmer K, Zani F, Habegger KM, Neff C, Kotzbeck P, Bauer M et al

However, overall chronic inflammation morphologically is characterised by the presence of macrophages, as is also evidenced by macrophage infiltrates seen in biopsies of FD patients as described above (16)

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Oncometabolites like succinate, fumarate, and 2-hydroxyglutarate, arising due to mutations in metabolic enzymes like SDH, FH, and IDH, have been linked to changes in DNA and histone modifications, further leading to the activation of EMT and enhancement of cancer stemness properties [28]

doi: 10.3390/nu17071222 482 MalikYSPathaniaADeUKPanwarHKaurJMishraAet al