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Wu and Ng addressed this directly in 1993, reporting that a synthetic peptide corresponding to residues 177 to 191 of hGH reproduced the antilipogenic activity of the intact molecule in isolated rat adipose tissue, with a magnitude comparable to the full hormone [1]
Experimental evidence from knockout models suggests that reduced NNMT activity is associated with resistance to tumor formation, leading to speculation about a possible role for this enzyme in cancer biology
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This is achieved, in part, by modulating the expression of pro-angiogenic factors such as Vascular Endothelial Growth Factor (VEGF) and Fibroblast Growth Factor 2 (FGF-2)
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