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Specifically, thyroid receptor 2 (TR2) is required for the correct expression of opsins in cone photoreceptors 58 and loss of this receptor shifts spectral sensitivity curves and retinal ERG responses in zebrafish 99,100

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Framed in this way, the rationale for their continued development as disease-modifying therapies in NDDs is strong, but must now be matched by well-designed, biomarker-rich clinical trials

Mixing them together can increase these effects and potentially lead to heart failure, heart attack or a heart rhythm disorder

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