Abstract Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-1), declines over time until only low levels can be detected in individuals aged 60 years
This slow ramp-up has a physiological background: the body adapts to the delayed gastric emptying and the strengthened satiety signal, so that nausea and vomiting subside at a stable dose
Mild swelling, bruising, or discomfort at the injection site may occur temporarily
High levels of solar elastosis have been observed in the skin of melasma patients
It aims at multiple receptors, including those for GLP-1, GIP, and others related to energy balance
Practical experience by knowledgeable hobbyists over several years and in several countries suggests that IR is a good measure provided the device and method used are correct