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Cellular GSSG accumulation, as opposed to GSH reduction, rendered hepatocytes susceptible to TNF cytotoxicity Increased GSSG/GSG ratios in response to H 2 O 2 exposure can stem from both GSH reduction and GSSG accumulation (data not shown)

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95%CI, 0.331.96, P = 0.006) and sequential administration subgroup (MD, 1.19

A meta-analysis in 2016 including 34 papers that measured changes in HDL-C levels before and after treatment with a GLP-1 RA found five studies showing a significant increase in HDL-C levels and 29 studies showing no significant change in HDL-C levels [69]

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