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Early treatment with intramuscular hydroxocobalamin is essential to prevent permanent complications, though established neuropathy may not fully recover even with treatment

Expressions of oncogenic proteins phospho-Akt and SIRT1 were decreased

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In clinical trials, 100% of healthy volunteers experienced this chromaturia with administration of 5g hydroxocobalamin with other common effects including erythema, rash (predominantly acneiform appearance) and increased blood pressure

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