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The HAS (French National Authority for Health) opinions are favorable, but negotiations between the CEPS (French Economic Committee for Health Products) and the pharmaceutical companies have not yet been finalized

Prescription and administration: Once B12 deficiency is confirmed, GPs prescribe hydroxocobalamin injections according to standardised protocols: Standard loading regimen: 1mg intramuscularly three times weekly for two weeks Neurological involvement: 1mg intramuscularly on alternate days until no further improvement Maintenance therapy: 1mg every three months for life in pernicious anaemia or malabsorption conditions (or every two months if there was neurological involvement) Injections are typically administered by practice nurses at GP surgeries

Typically, users seeking skin benefits might observe changes after several sessions

Secondary hemodialysis deficiencies: 2 - 4 grams per day

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Splitting the dose (morning and afternoon) may help maintain steadier levels of dietary vitamin C in the blood