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Therefore, it is recommended to refrain from its use during the first 10 weeks of gestation, a period marked by heightened fetal susceptibility to teratogens ( Mycophenolate mofetil Avoidance of this medication is imperative during pregnancy due to its association with increased risks of first-trimester pregnancy loss and a heightened incidence of congenital malformations ( To mitigate these risks, it is recommended to discontinue mycophenolate at least 6 weeks before conception ( Methotrexate Administering methotrexate before and during pregnancy carries the potential for lasting consequences on fetal growth ( Leflunomide It is cautioned to be avoided during pregnancy based on the results of preclinical reproductive studies, although its definitive teratogenicity in humans remains uncertain

The next breakthrough may come from an equally unlikely source

Rare Vision Events (NAION) Rare vision complications, including non-arteritic anterior ischemic optic neuropathy (NAION), have been reported in post-marketing data

Lower calorie intake may alter levels of hormones that influence alertness and rest, which can subtly affect how sleepy you feel at night

These effects are often related to how the medication changes gut motility and digestion

14,15 Potential Direct Effects on the Heart Although the systemic indirect effects of GLP-1RAs are well established as the primary drivers of their clinical benefit in HF, emerging preclinical and mechanistic evidence suggests GLP-1RAs may also exert some direct cardioprotective effects, as discussed below