An alternative approach that has been explored experimentally in the porcine ischemic injury model to limit formation of LA inhibitory fragments while maintaining the ability of LA to induce recovery of barrier function involves addition of small doses of LA over time and suggest that 0.1 M LA applied every 45 min is effective (49)
For a 10mg vial providing 5 doses at 2mg each, dead space losses of approximately 1 unit per draw mean roughly 5 units (50mcg at 10mg/mL) lost total
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Dosage adjustments should be made accordingly
