Thus, the determination of GSNO can be affected by light, metal-catalyzed GSNO decomposition, enzymatic degradation as a result of endogenous GSNO reductase activity and a reduction in the S -NO bond caused by reductants and endogenous thiols
Animal colitis studies showing oral efficacy do not resolve whether the effect is local or systemic
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For example, in a mouse model of mucopolysaccharidosis (MPS VII), transgene delivery of b-glucuronidase in neonatal mice using an AAV2 vector resulted in the mice developing hepatocellular carcinoma (HCC)with evidence of AAV integration within the tumors [149, 150]
Intranasal administration is valued as a non-invasive means of both systemic and local administration with good bioavailability, rapid onset, and targeted effects on the central nervous system [13, 14]
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