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While this can be beneficial for drugs with low bioavailability or metabolic stability, this pharmacokinetic alteration can have a negative impact on drugs with an extremely narrow therapeutic index, such as captopril, lisinopril, and digoxin (Fasinu, Bouic, and Rosenkranz, 2012)

For instance, in breast cancer cells, the intracellular pool of labile ions is twice as elevated as in normal breast epithelial cells

There are 5 melanocortin receptors ranging from MC1R to MC5R

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