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Center for Internal Medicine

The standard adult dose during pregnancy, as recommended by most OBs, is 325 to 500 mg every 4 to 6 hours as needed, not exceeding 3,000 to 4,000 mg in 24 hours

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Malonylation of histone H2A at lysine 119 inhibits Bub1-dependent H2A phosphorylation and chromosomal localization of shugoshin proteins

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