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Researchers have confirmed that ferroptosis leads to RPEC loss, disrupts mitochondrial function, and increases lipid peroxidation in ferric ammonium citrate (FAC)-treated ARPE-19 cells and mouse models

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Fibroblast-like synoviocytes (FLSs) contribute to pannus formation and matrix degradation through MMP-1 and MMP-3, with expression levels 5 - 10 times higher in RA synovium (Figure 1) (14)

2024;7(11) doi: 10.1001/jamanetworkopen.2024.33000

Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease