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Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease

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However, occasional late-emerging symptoms and discontinuation patterns still require attention

Coumaphos significantly decreased the K m of recombinant HlGST, indicating the apparent activation of the enzyme

Further, the mutant atgsnor13 was also perturbed in thermotolerance and resistance to paraquat (1,1 -dimethyl-4,4 -bipyridinium dichloride), which induces the production of superoxide and H 2 O 2 in wild type leaves ( Arabidopsis GSNOR1/HOT5/PAR-2 gene not only regulates SA signaling and thermotolerance by modulating the intracellular SNO level, but also acts downstream of superoxide to regulate cell death