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GI Adverse Effects of Glucagon-Like Peptide-1 Receptor Agonists These agents are commonly used therapies for managing diabetes and obesity, but gastrointestinal adverse effects such as nausea, vomiting, diarrhea, and constipation frequently limit therapy

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Importantly, early studies show that Retatrutide does not introduce unique or unexpected risks beyond those already seen in GLP-1 and GIP receptor agonists