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So far, no significant hypoglycaemia signal has been seen, likely because GLP-1 and GIP agonism counterbalance glucagons glucose-raising effect, but this remains an area of ongoing surveillance

The introduction of a triple-agonist peptide threatens to replace current GLP-1 drugs as the dominant weight-loss therapy once the compound enters mainstream healthcare

Balanced macronutrients in smaller servings help avoid nausea or heavinesssomething many GLP-1 users experience, says Angel Roque, culinary director of Cuba Libre Restaurant

Weight loss was only part of the picture

Some people must avoid semaglutide, particularly those with personal or hereditary medullary thyroid carcinoma history or multiple endocrine neoplasia syndrome type 2

Diabetes Care (2012) 35(7):144654