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Targeted evaluation is most appropriate when elevation is unexplained, persistent, or paired with red-flag features, with functional markers added when deficiency remains plausible despite a high total

Vitamin C In 48 individuals with ascorbate deficiency [87], taking 500 or 1000 mg per day of vitamin C for 13 weeks led to an 18% increase in lymphocyte glutathione levels compared with placebo

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[Pathogenesis and epidemiology of arterial hypertension]

This is a hypothesis-level consideration that has driven comparative research