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By bypassing the body's natural protective barriers, such as the gastrointestinal tract and the liver's first-pass metabolism, the administered substances enter the systemic circulation without the usual filtering or processing mechanisms

Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration of the spinal cord

Oxidative stress, which increases with age, depletes the levels of glutathione

doi: 10.2119/molmed.2010.00107

Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis