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Resulting adducts were analyzed using bottom-up proteomics, with or without LC fractionation prior to LC-MS/MS analysis on a quadrupole-time-of-flight instrument with data-dependent acquisition (DDA)

Consequently dobutamine can paradoxically result in decreased CO in patients with IHSS, despite the increase in inotropy, resulting in hypotension, syncope, worsening of ischemia & arrhythmias (Dimitrow & Rajtar-Salwa, 2016

Both compounds have shown potent protective effects in diverse preclinical models, including renal IRI, traumatic brain injury, and sepsis-induced acute lung injury (Thapa et al., 2022