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The condition encompasses a spectrum of pathophysiologic processes ranging from absolute insulin deficiency (Type 1) to progressive insulin secretory failure superimposed on insulin resistance (Type 2)

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Most patients shift to monthly injections after initial weekly repletion

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Legal status (US): Sermorelin has a documented, two-part FDA approval history under the brand name Geref, both approvals held by Serono (later EMD Serono)