There are a number of medical conditions and or medicines that may affect the decision to treat

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Vitamin B12 Supplementation in Diabetic Neuropathy MDPI article: Investigates daily methylcobalamin in type 2 diabetes neuropathy patients with B12 deficiency
It outlines circumstances in which vitamin B12 deficiency is more more common, such as in older people
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This modification, a subtype of S-thiolation, involves the formation of mixed disulfide bonds between glutathione and the cysteine residues of target proteins