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By employing a multi-omics approachintegrating bulk and single-cell transcriptomics with epigenetic profilingwe investigated the potential contribution of these exosomes to myocardial injury

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doi: 10.3389/fphar.2023.1224623 152 La MendolaDTrincavelliMLMartiniC

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For example, the variant 677T is most commonly associated with cerebral vascular accident (stroke), elevated homocysteine, cardiovascular disease risk, peripheral neuropathy, deep vein thrombosis, early-onset heart disease, stillbirth, neuro-tube defect, cleft lip, and preeclampsia

Further, when THBP was co-incubated with either NAC, NACET, or diNAC (two NAC molecules bridged via disulfide bond, masking the active thiol) for 9 h, a concentration-dependent reduction in ROS generation was observed (Fig