By contrast, ChaC1 induces ferroptosis in tumor cells by activating the GCN2/EIF2/ATF4 pathway to intensify cystine depletion (116)
These persister cells are antibiotic-tolerant variants of Lyme bacteria, meaning they are generally unresponsive to drugs
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The levels of mitochondrial ROS, as measured by mitoSOX, were also greatly elevated upon tBHP stimulation, which was also abrogated by FTMT overexpression (Fig
References Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global Cancer Statistics 2020, GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries