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8 Calibration of efficacy model
Despite its efficacy, therapy is deliberately restricted to a maximum cumulative duration of five days in adults because prolonged systemic exposure is associated with a rising incidence of gastrointestinal bleeding, renal dysfunction, and cardiovascular adverse events
If the body properly uses B12, studies show it can stay in the body for up to five years
A proposed molecular mechanism of MSG-induced ROS production is that chronic MSG exposure increases the production of Glutamate which may raise the activity of one of the potential ROS generators like -ketoglutarate dehydrogenase in the rat kidney
This could potentially reduce absorption and effectiveness
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