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During embryonic stages, the body relies on specific signaling molecules to drive growth and organization, and reintroducing molecules like T4 later in life may help reawaken those regenerative pathways, particularly following cardiac injury

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In 1964, the development of insulin radioimmunoassay methods led to the discovery of the incretin effect, which demonstrated that oral glucose intake induces higher insulin secretion compared to intravenous (i.v.) glucose [3,4]