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The table matches routes to situations: oral cyanocobalamin when baseline B12 is normal-low with intact absorption, intramuscular injections when baseline is deficient or absorption is poor, sublingual lozenges when stomach acid or intrinsic factor is reduced, and the active form for certain metabolic differences

It affects approximately 50% of men by age 50 and a significant proportion of women

Acids such as citric acid, lactic acid should be added to adjust the pH

Van Pelt RE, Gozansky WS, Schwartz RS, Kohrt WM

Moreover, the engulfment of hepatocyte ABs by nave hepatocytes spreads cell death and inflammation in the liver