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GSH acts as a detoxifying agent by direct conjugation to a xenobiotic (X) forming a glutathione-S conjugate as part of the mercapturic acid pathway that leads to the elimination of toxic compounds

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Pyruvate dehydrogenase kinases (PDKs) are mitochondrial enzymes that inhibit the pyruvate dehydrogenase complex, which controls pyruvate entry into the tricarboxylic acid cycle and the subsequent adenosine triphosphate production required for normal cellular activities

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doi: 10.1007/s10571-024-01496-z 201 ZengMPengMLiangJSunH