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The weight loss in the SELECT trial ( 9.39%) was 35% less than weight loss delivered in semaglutides STEP 1 trial (14.9%)

Post-marketing data and pharmacovigilance registries have suggested a possible association between GLP-1 RA and acute pancreatitis although this remains controversial [9,10,11,12]

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Put another way, how fast does tesamorelin work and tesamorelin time to work depend on the endpoint: early IGF-1 and lab-marker shifts can appear sooner, while the best-known VAT/body-composition outcome is a 26-week clinical trial endpoint

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The compound is not yet approved by Health Canada, as it remains in clinical trials with FDA approval projected for 2026 or 2027