| | 5-Amino-1MQ Monotherapy | None | 50100mg daily | Daily oral or subcutaneous | NNMT inhibition preserves NAD+, activates AMPK and mitochondrial fat oxidation | 812 weeks | Promising preclinical data
Phase 1 (Day 0-7) was characterized by rapid weight loss, particularly following the first day of treatment
Obese patients in the real world tend not to be very compliant and not to follow the lifestyle change recommendations needed to show the promise delivered during clinical trials
Compounded semaglutide starts at $175 for the first month and $225 monthly thereafter
This is especially important for prescription weight loss medications, including GLP-1 treatments, because patients should receive care from a legitimate medical provider with appropriate screening, prescribing, monitoring, and follow-up
Additional Ingredients Many compounded semaglutide preparations include ingredients not found in Wegovy, most commonly vitamin B12