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A cushingoid appearance usually indicates that the glucocorticoid dose is excessive

Lung, WAT, testis, and skeletal muscle preferentially rely on salvage and have low expression of proteins involved in the PreissHandler pathway 41 , with the muscle in particular relying on both NRK1 and NRK2 for supporting its mitochondrial metabolism and fiber type composition 42

This cycle may be repeated numerous times and results in significant muscle wasting in patients, thereby increasing the risk of falls and fractures, particularly in the elderly population

Gastrointestinal and Gallbladder Effects Gastrointestinal symptoms are usually dose-related and may be mitigated by slower titration and taking smaller, lower-fat meals during the first weeks

Because many people eat significantly lesssuch as 35% fewer total calories 4 while taking these medications, according to recent researchit becomes especially important to prioritize a nutrient-dense diet in order to limit deficiencies and the side effects they can cause

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