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Clinically significant weight lossgenerally defined as 5% or more of baseline body weighttypically becomes apparent after reaching the maintenance dose, which may take 16-20 weeks depending on the specific medication and titration schedule

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Stimulation of adenosine 3, 5monophosphate production by growth hormonereleasing factor and its inhibition by somatostatin in anterior pituitary cells in vitro

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Over a 48-hour period: 12 g or 300 mg/kg, or Over a 48-hour period: 4g/d in patients with RUQ pain or N&V