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Reducing the risk of harm from medication errors in children

Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD

Elghazawy NH, Engel M, Hartmann RW, Hamed MM, Ahmed NS, Abadi AH

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Headache: Some people get headaches, especially when first starting the medication

ZWF1 encodes glucose6phosphate dehydrogenase, the enzyme that provides the majority of NADPH for the cytosol, but not for the matrix