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10.1016/j.ijbiomac.2024.130897 Summary Keywords acute toxicity testing, chlorogenic acid, hepatocellular injury, hepatocyte protection, iron deficiency, polyphenol Citation Pang Y, Jiang M, Ge B, Huang L, Rao X, Wang X, Zhou H, Lyu J, Wang Z and Tan G (2026) Safe dosage and potential risks of chlorogenic acid: insights from in vitro and in vivo studies

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For example, IF has been shown in overweight and obese human subjects during Ramadan to modulate expression of SIRT1, SIRT3, and antioxidant genes, though results are mixed and often depend on gene expression rather than direct functional assays [38]