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Microglia are transformed into DAM by recognizing Neurodegeneration-Associated Molecular Pattern (NAMP) danger signals which leak from damaged neuronal cells in analogy to the peripheral immune systems pathogen- and damage-associated stress signals (PAMPs and DAMPs) 23

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Eur J Clin Pharmacol 75, 2131 (2019)

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Given pregabalins central 2 subunit modulation and thioctic acids peripheral ion channel and oxidative stressmediated effects, the observed synergy is pharmacologically plausible

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