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Dematiaceous fungi typically generate more diffuse pigmentation, while non-dematiaceous fungi induce melanocytic activation.7,8 Some authors suggest that non-dematiaceous fungi induce inflammation and subsequent melanin production by the melanocytes of the nail matrix (hypermelanosis).9 However, there are studies supporting the idea that Trichophyton rubrum is capable of producing melanin or melanin-like compounds, both in vitro and in vivo.10 The clinical characteristic that distinguishes fungal melanonychia from nail melanoma is the presence of multiple colors, ranging from golden yellowish-brown to dark gray, predominantly clustered in the distal portion of the nail plate

J.RezaeiM.AlipoorE.Vasheghani-FarahaniA.YaseriM.et al (2024)

Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder

However, in terms of immune system effects, there is limited evidence indicating that DPP4 inhibition impairs immune function

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