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Engineering and characterization of the long-acting glucagon-like peptide-1 analogue LY2189265, an Fc fusion protein

Data are represented as median and IQR

The analysis could be affected by residual confounding from unsupervised lifestyle modifications, and importantly, the reasons for treatment discontinuation were not recorded

The DMH is involved in stimulating gastrointestinal activity

Identity and purity of every batch - including HPLC purity, appearance, and relevant physicochemical parameters - are documented on the lot-specific Certificate of Analysis, available on request to support formulators' own specification and QC programs

Kinetic parameters were determined using multiple cycles, response signals were plotted versus analysis time and fitted to a 1:1 Langmuir binding model using BIAcore T200 software to obtain binding and dissociation rate constants