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271 Emerging preclinical evidence suggests the potential of metformin in ameliorating NAFLD

Experimental validation results To experimentally validate the core targets and pathways identified through our integrated bioinformatics analysis, we first established a rat model of T2DM-associated MASLD

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HUVECs are derived from large vessels of the umbilical cord and represent only one subtype of ECs, while different tissues possess specialized EC populations with unique immunomodulatory roles

Safety Considerations: Medication interactions with current drugs Health conditions that increase risk Ability to safely use medication Need for additional monitoring Patient Understanding: Does patient understand how medication works