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Patients should work with healthcare providers to ensure nutritional adequacy during treatment, including folic acid supplementation (400-800 mcg daily) for those who might become pregnant

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As part of the study, researchers used the DEXA technique to assess body composition and monitor the effects of semaglutide therapy on total body and stomach fat in 140 participants

These are only two studies among hundreds of other trusted PRP publications Their findings, while thought-provoking, are not yet universally supported across the broader PRP literature They genuinely represent early directional insights, but are not representative of the data As is the fickle world of published clinical data, a much larger systematic review and meta-analysis of 34 randomised controlled trials by Simental-Menda et al (2025) found no consistent relationship between higher absolute platelet count and better clinical outcomes in knee OA

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Notably, semaglutide and exenatide showed higher NAE proportions (16.97% and 14.44%, respectively) compared to tirzepatide (6.06%)